Materials Literature
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Abstract Multiple Myeloma (MM) is a recurring-relapsing plasma cell malignancy, which invariably develops drug resistance. Acquired resistance often involves mutation of drug targets or activation of compensatory pathways, making new targets in high demand. Physical contact of MM cells (MMC) with the bone microenviron…
Abstract Triapine, which is currently tested in a clinical phase III trial, is the best-studied thiosemicarbazone (TSC) for anticancer therapy. With regard to the mode of action, anticancer activity of TSCs is frequently linked to their ability to chelate essential metal ions such as copper and iron. As Triapine monot…
Abstract Despite Pancreatic cancer being expected to contribute to only 3% of new cancer cases in both males and females in 2019, it is expected to cause an estimated 45,750 deaths making it the third highest contributor to cancer deaths. This is due to the low survivability associated with pancreatic cancer which has…
Abstract Background: Activation of the innate immune system and natural killer (NK) cells has been a key effort in cancer immunotherapy research. Several NK-cell-targeted therapeutics are under clinical investigation. Current research is focused on bispecific antibodies that can bind to and target both tumor cells and…
Abstract Many traditional nanoparticle delivery mechanisms require the use of an inert vehicle to deliver single therapeutic payloads. Here, we describe a novel, dual-therapeutic, self-assembled nanoparticle class wherein both the payload and encapsulating vehicle may potentiate anti-neoplastic effects. The nanopartic…
Abstract Glioblastoma multiforme (GBM) remains characterized by poor clinical outcomes and limited treatment options. Currently, the standard of care for patients with this disease is surgery with radiation therapy and concurrent and adjuvant temozolomide. However, most patients succumb to the disease within the first…
Abstract Macrophage in tumors in the M2 immunosuppressive state have been shown to play a role in reducing the effectiveness of immunotherapy and facilitating metastases formation. Many current approaches to targeting macrophage are not selective to the tumor microenvironment potentially resulting in systemic proinfla…
Abstract Immunogenic cell death characterized by the release of damage-associated molecular patterns (DAMPs) from dying cancer cells is a potential contributor to the synergistic antitumor effects of the combination of cytotoxic chemotherapy with immune checkpoint blockade. However, little information on the kinetics…
Abstract One of the major challenges in breast cancer treatment is the high toxicity associated with cytotoxic agents. To overcome this issue, we developed nanoparticles conjugated with cancer cell specific antibodies (trastuzumab) to improve drug delivery to the tumor, while sparing healthy tissues. These antibody na…
Abstract Triple negative breast cancers (TNBCs) represent 15-20% of all breast cancers and are defined by lack of the estrogen and progesterone receptors and HER2 gene amplification. Therefore, TNBC patients do not benefit from available therapies targeting these receptors. The significant heterogeneity of TNBC preclu…
In this paper, a gas permeable waterproof film with superhydrophobic characteristics of irregular microstructures and vertical microchannels, is presented. A wet etching technique of aluminum alloys was employed for the preparation of a superhydrophobic surface, and a typical punching technique was used for the fabric…
Abstract Purpose: Lack of standard treatment of Primary Central Nervous System Lymphoma (PCNSL) was acknowledged in phase III intergroup study (HOVON 105/ALLG NHL 24). PCNSL incidence is increasing for unknown reasons, particularly among persons over 65 years of age. The major limitation of successful treatment of PCN…
Abstract Introduction: It has been known for over a century that all living systems develop radiation resistance under hypoxic conditions - low pO2. But giving extra radiation - dose painting - or boosting hypoxic tumors regions has not shown enhanced control in mammalian tumors. Pulse EPR quantitative pO2 values can…
Abstract Small molecule anticancer drugs are potent and effective agents against a variety of malignancies. However, severe side effects are often associated with their application due to systemic toxicities caused by their indiscriminate infiltration into normal tissues, organs, and cells. Using natural human serum a…
Abstract Solar ultraviolet (UV) light-induced non-melanoma skin cancer is the most common type of cancer diagnosed in the United States and remains one of the major public health concerns. There is an urgent need to develop effective and safe skin cancer chemopreventive agents. We have previously demonstrated that car…
Abstract Quantitative, noninvasive imaging utilizing the full potential of antibody targeted nanomedicines has recently emerged as a new paradigm in cancer therapeutics. However, the specificity of these nanomedicines to the molecular targets in in vivo is much controversial. We have leveraged a molecular-specific app…
Abstract Background: Temozolomide (TMZ) is a DNA alkylating prodrug used for the treatment of malignant, glioblastoma multiforme (GBM) tumors. Yet, TMZ therapy is blighted by resistance systems in GBM that thwart eradication of all cancer cells remaining after surgery and radiotherapy. Resistance mechanisms include dr…
Abstract Prostate cancer is the leading cause of cancer death in American men. The high mortality rate is attributable to current treatments not providing a cure for hormone-refractory prostate cancer. The main goal of this project is to provide a novel therapeutic approach based on nanoparticle-mediated magnetic hype…
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In this study, the single point incremental forming (SPIF) method was applied to the half spherical-shaped vent cap products with 1mm thickness of aluminium. The dimensions of the blank before forming is 1x Ø225mm, and the final dimensions of the product are 69.50 x Ø225mm. Blank material is gripped to the fixture exp…