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Multifunctional HNT@Fe 3 O 4 @PPy@DOX Nanoplatform for Effective Chemo-Photothermal Combination Therapy of Breast Cancer with MR Imaging

Xiang Luo、Jun Zhang、Yanping Wu 等 9 位作者2020-05-13ACS Biomaterials Science & Engineering

Multifunctional nanoparticles for imaging and treatment in cancer are getting more and more attention recently. Herein, halloysite nanotubes (HNTs), natural clay nanotubes, are designed as multifunctional nanoplatform for targeted delivering photothermal therapy agents and chemotherapeutic drugs. Fe 3 O 4 was anchored…

Nanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research Studies

Preferential Control of Forward Reaction Kinetics in Hydrogels Crosslinked with Reversible Conjugate Additions

Thomas M. FitzSimons、Felicia Oentoro、Tej V. Shanbhag 等 5 位作者2020-05-13Macromolecules

Molecular substitutions were used to demonstrate preferential control over the kinetic rate constants in a poly(ethylene glycol)-based hydrogel with two different reversible thia-conjugate addition reactions. A strong electron-withdrawing nitrile group on the conjugate acceptor showed a 20-fold increase in the forward…

Hydrogels: synthesis, properties, applicationsAdvanced Polymer Synthesis and CharacterizationPolymer composites and self-healing

Targeted uptake of folic acid-functionalized polymeric nanoparticles loading glycoalkaloidic extract in vitro and in vivo assays

Mariza Abreu Miranda、L.B. Silva、Ivana Pereira Santos Carvalho 等 12 位作者2020-05-13Colloids and Surfaces B Biointerfaces

Solanum lycocarpum fruits contain two major glycoalkaloids (GAs), solamargine (SM) and solasonine (SS). These compounds are reported as cytotoxic. However, they have poor water solubility and low bioavailability. To overcome these disadvantages and getting an efficient formulation the current study aimed to develop, c…

Carbon and Quantum Dots ApplicationsPotato Plant ResearchPhytase and its Applications

Atomic-Level Drug Substance and Polymer Interaction in Posaconazole Amorphous Solid Dispersion from Solid-State NMR

Xingyu Lu、Mingyue Li、Chengbin Huang 等 9 位作者2020-05-13Molecular Pharmaceutics

Despite the wide utilization of amorphous solid dispersions (ASDs) for formulating poorly water-soluble drugs, fundamental understanding of the structural basis behind their stability and dissolution behavior is limited. This is largely due to the lack of high-resolution structural tools for investigating multicompone…

Advanced NMR Techniques and ApplicationsSolid-state spectroscopy and crystallographyMuon and positron interactions and applications

Discovery and Characterization of a New Cold-Active Protease From an Extremophilic Bacterium via Comparative Genome Analysis and in vitro Expression

Amedea Perfumo、Georg Johannes Freiherr von Sass、Eva-Lena Nordmann 等 5 位作者2020-05-13Frontiers in Microbiology

Following a screening of Antarctic glacier forefield-bacteria for novel cold-active enzymes, a psychrophilic strain Psychrobacter sp. 94-6PB was selected for further characterization of enzymatic activities. The strain produced lipases and proteases in the temperature range of 4-18ºC. The coding sequence of an extrace…

Enzyme Structure and FunctionProtein Hydrolysis and Bioactive PeptidesEnzyme Production and Characterization

Efficiency of bentonite in removing cesium, strontium, cobalt and uranium ions from aqueous solution: encapsulation with alginate for column application

R. A. Abou-Lilah、Hoda E. Rizk、Mostafa A. Elshorbagy 等 6 位作者2020-05-13International Journal of Environmental & Analytical Chemistry

Raw bentonite was characterised and employed for adsorption of Cs(I), Sr(II), Co(II) and U(VI) from aqueous solution. Batch adsorption methodology was applied to study the factors influencing the adsorption capacity of bentonite. Thermodynamic parameters, ΔH°, ΔS°, and ΔG° were calculated and revealed that the sorptio…

Radioactive element chemistry and processingCovalent Organic Framework ApplicationsChemical Synthesis and Characterization

The Role of Electron Localization in Covalency and Electrochemical Properties of Lithium‐Ion Battery Cathode Materials

Xuelong Wang、Xiulin Fan、Xiqian Yu 等 14 位作者2020-05-13Advanced Functional Materials

Abstract Following the fundamental research conducted by J. B. Goodenough, the important role of electron localization induced by elemental substitution is studied. The size and electron negativity of host and substituting ions are two important factors in tuning material properties such as local structure and transit…

Advancements in Battery MaterialsAdvanced Battery Materials and TechnologiesElectron and X-Ray Spectroscopy Techniques

A Humidity‐Induced Nontemplating Route toward Hierarchical Porous Carbon Fiber Hybrid for Efficient Bifunctional Oxygen Catalysis

Lidong Tian、Dongxiao Ji、Shan Zhang 等 6 位作者2020-05-13Small

Abstract Hierarchical porous carbons (HPCs) are highly efficient supports for various remarkable catalytic systems. However, templates are commonly utilized for the preparation of HPCs, and the postremoval of the templates is uneconomical, time‐consuming, and harmful for the environment in most cases. Herein, a new hu…

Electrocatalysts for Energy ConversionCatalytic Processes in Materials ScienceCovalent Organic Framework Applications

A Comprehensive Review of the Mycelial Pellet: Research Status, Applications, and Future Prospects

Lixin Li、Taojie Liang、Wanmeng Liu 等 5 位作者2020-05-13Industrial & Engineering Chemistry Research

The mycelial pellet is a microbial aggregator formed under certain conditions. Besides the ability to secrete metabolites and adsorb a large amount of pollutants, the mycelial pellet has the characteristics of high biological activity, fast sedimentation speed, and easy solid–liquid separation. The technology of the m…

Catalytic Processes in Materials ScienceAlgal biology and biofuel productionProcess Optimization and Integration

TiO2 nanotubes synthesised on Ti-6Al-4V ELI exhibits enhanced osteogenic activity: A potential next-generation material to be used as medical implants

Subhasmita Swain、R.D.K. Misra、Chang Kuk You 等 4 位作者2020-05-13Materials Technology

Ti-6Al-4 V and Ti-6Al-4 V ELI alloys were surface modified with nanotube layers by electrochemical anodisation technique. Osteoblast cell viability and their osteogenic behaviour were studied. It was found that the pore diameters of the nanotubes were in the range of 70–105 nm for Ti-6Al-4 V sample and 60–130 nm for T…

Bone Tissue Engineering MaterialsOrthopaedic implants and arthroplastyTitanium Alloys Microstructure and Properties

High Critical Current Density and Enhanced Pinning in Superconducting Films of YBa2Cu3O7−δ Nanocomposites with Embedded BaZrO3, BaHfO3, BaTiO3, and SrZrO3 Nanocrystals

Javier Díez-Sierra、Pedro López-Domínguez、Hannes Rijckaert 等 16 位作者2020-05-13ACS Applied Nano Materials

Chemical solution deposition (CSD) of YBa 2 Cu 3 O 7−δ (YBCO) nanocomposites from colloidal precursor solutions containing double metal oxide preformed nanocrystals is a promising, cost-effective, and reproducible approach to producing superconducting films with high critical current density ( J c ) and enhanced pinni…

Physics of Superconductivity and MagnetismZnO doping and propertiesSuperconductivity in MgB2 and Alloys

Emerging Concepts of Nanobiotechnology in mRNA Delivery

Yue Wang、Chengzhong Yu2020-05-13Angewandte Chemie International Edition

Introducing mRNA into cells has attracted intense interest for diverse applications; however, success requires delivery solutions. Engineered nanomaterials have been applied as mRNA nanocarriers; their functions are designed mainly as delivery vehicles, but rarely in regulation of the protein translation. Recently, pr…

Advanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryMXene and MAX Phase Materials

Recent Advances in Chemical Biology Using Benzophenones and Diazirines as Radical Precursors

Muhammad Murtaza Hassan、Olasunkanmi O. Olaoye2020-05-13Molecules

The use of light-activated chemical probes to study biological interactions was first discovered in the 1960s, and has since found many applications in studying diseases and gaining deeper insight into various cellular mechanisms involving protein-protein, protein-nucleic acid, protein-ligand (drug, probe), and protei…

Radical Photochemical ReactionsClick Chemistry and ApplicationsPhotochromic and Fluorescence Chemistry

Efficient Modeling of Organic Chromophores for Entangled Two-Photon Absorption

Gyeongwon Kang、K. Nasiri Avanaki、Martín A. Mosquera 等 7 位作者2020-05-13Journal of the American Chemical Society

Abstract The use of a nonclassical light source for studying molecular electronic structure has been of great interest in many applications. Here we report a theoretical study of entangled two-photon absorption (ETPA) in organic chromophores, and we provide new insight into the quantitative relation between ETPA and t…

Quantum Information and CryptographyQuantum Dots Synthesis And PropertiesNonlinear Optical Materials Studies

Modulation of J-Aggregation of Nonfullerene Acceptors toward Near-Infrared Absorption and Enhanced Efficiency

Xue Zhang、Hui Wang、Donghui Li 等 12 位作者2020-05-13Macromolecules

The molecular aggregation of nonfullerene acceptors (NFA) can significantly affect the light absorption, charge generation, and power conversion efficiency (PCE) of organic solar cells (OSCs). In this work, we demonstrate the regulation of J-aggregation of CO i 8DFIC NFA toward near-infrared absorption via solvent add…

Organic Electronics and PhotovoltaicsConducting polymers and applicationsNonlinear Optical Materials Research

Electrospun PLGA Fiber Diameter and Alignment of Tendon Biomimetic Fleece Potentiate Tenogenic Differentiation and Immunomodulatory Function of Amniotic Epithelial Stem Cells

Mohammad El Khatib、Annunziata Mauro、Miriam Di Mattia 等 15 位作者2020-05-13Cells

Injured tendons are challenging in their regeneration; thus, tissue engineering represents a promising solution. This research tests the hypothesis that the response of amniotic epithelial stem cells (AECs) can be modulated by fiber diameter size of tendon biomimetic fleeces. Particularly, the effect of electrospun po…

Electrospun Nanofibers in Biomedical ApplicationsWound Healing and TreatmentsTendon Structure and Treatment

CuS–NiS2 nanomaterials for MRI guided phototherapy of gastric carcinoma via triggering mitochondria-mediated apoptosis and MLKL/CAPG-mediated necroptosis

Jian Chen、Rongjun Zhang、Cheng Tao 等 12 位作者2020-05-13Nanotoxicology

Gastric carcinoma is one of the most lethal malignant tumors. As part of our long-term efforts on seeking effective diagnosis and therapeutic strategies of gastric cancer, we present herein novel ternary copper-based chalcogenide nanoplatform CuS–NiS2 nanomaterials with outstanding photothermal (PT)/photodynamic (PD)…

Extracellular vesicles in diseaseNanoplatforms for cancer theranosticsAdvanced Nanomaterials in Catalysis

Tuning of the Aggregation Behavior of Fluorinated Polymeric Nanoparticles for Improved Therapeutic Efficacy

Cheng Zhang、Tianqing Liu、Wenqian Wang 等 12 位作者2020-05-13ACS Nano

Incorporation of fluorinated moieties in polymeric nanoparticles has been shown in many instances to increase their uptake by living cells and, hence, has proven to be a useful approach to enhancing delivery to cells. However, it remains unclear how incorporation of fluorine affects critical transport processes, such…

Nanoparticle-Based Drug DeliveryAdvanced Polymer Synthesis and CharacterizationPolymer Surface Interaction Studies

Conductive Boron Nitride as Promising Catalyst Support for the Oxygen Evolution Reaction

Hui Liu、Xinghua Zhang、Ying‐Xin Li 等 10 位作者2020-05-13Advanced Energy Materials

Abstract Catalyst support with good conductivity and stability is an eternal pursuit in the search for a high‐performance electrocatalyst. Here, an unusual catalyst support, laser‐modified boron nitride with C, O dopants (L‐BN), for the oxygen evolution reaction is reported. L‐BN exhibits unique advantages for electro…

Electrocatalysts for Energy ConversionAdvanced Photocatalysis TechniquesMXene and MAX Phase Materials

Electron Paramagnetic Resonance as a Tool for Studying Membrane Proteins

Indra D. Sahu、Gary A. Lorigan2020-05-13Biomolecules

Membrane proteins possess a variety of functions essential to the survival of organisms. However, due to their inherent hydrophobic nature, it is extremely difficult to probe the structure and dynamic properties of membrane proteins using traditional biophysical techniques, particularly in their native environments. E…

Lanthanide and Transition Metal ComplexesAdvanced NMR Techniques and ApplicationsElectron Spin Resonance Studies