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Strategies for improving the intratumoral distribution of liposomal drugs in cancer therapy

Beth Goins、William T. Phillips、Ande Bao2016-03-16Expert Opinion on Drug Delivery

INTRODUCTION: A major limitation of current liposomal cancer therapies is the inability of liposome therapeutics to penetrate throughout the entire tumor mass. This inhomogeneous distribution of liposome therapeutics within the tumor has been linked to treatment failure and drug resistance. Both liposome particle tran…

Nanoparticle-Based Drug DeliveryUltrasound and Hyperthermia ApplicationsInhalation and Respiratory Drug Delivery

Investigations on RF-magnetron sputtered Co 3 O 4 thin films regarding the solar energy conversion properties

Christian Lohaus、Jan Morasch、Joachim Brötz 等 5 位作者2016-03-16Journal of Physics D Applied Physics

Abstract Co 3 O 4 samples have been deposited using RF-magnetron sputtering from an oxide target. In situ x-ray and ultraviolet photoelectron spectroscopy and x-ray diffraction have been carried out to identify the phase and composition of the films. The work function of films showed variation of about 1 eV depending…

ZnO doping and propertiesChalcogenide Semiconductor Thin FilmsCopper-based nanomaterials and applications

Quaternized Chitosan/Alginate-Fe<SUB>3</SUB>O<SUB>4</SUB> Magnetic Nanoparticles Enhance the Chemosensitization of Multidrug-Resistant Gastric Carcinoma by Regulating Cell Autophagy Activity in Mice

Xiujuan Li、Jing Feng、Ran Zhang 等 17 位作者2016-03-16Journal of Biomedical Nanotechnology

Multidrug resistance (MDR) and targeted therapies present major challenges in tumor chemotherapy. Nanoparticles (NPs) hold promise for use in cancer theranostics due to their advantages in terms of tumor-targeted cytotoxicity and imaging. In this study, we developed N-((2-hydroxy-3-trimethylammonium) propyl) chitosan…

Nanoparticle-Based Drug DeliveryDrug Transport and Resistance MechanismsNanoplatforms for cancer theranostics

“Grafting-Through”: Growing Polymer Brushes by Supplying Monomers through the Surface

Reihaneh Mohammadi Sejoubsari、Andre P. Martinez、Yasemin Kutes 等 6 位作者2016-03-16Macromolecules

We introduce a “grafting-through” brush polymerization mechanism where monomers are supplied through the surface on which the initiators are attached rather than from solution as in the “grafting-from” technique. This is accomplished by attaching the initiator to the surface of a dialysis membrane and supplying monome…

Polymer Surface Interaction StudiesAdhesion, Friction, and Surface InteractionsNanofabrication and Lithography Techniques

Weakened Flexural Strength of Nanocrystalline Nanoporous Gold by Grain Refinement

Eun‐Ji Gwak、Ju‐Young Kim2016-03-16Nano Letters

High density of grain boundaries in solid materials generally leads to high strength because grain boundaries act as strong obstacles to dislocation activity. We find that the flexural strength of nanoporous gold of grain size 206 nm is 33.6% lower than that of grain size 238 μm. We prepared three gold-silver precurso…

Electrocatalysts for Energy ConversionAnodic Oxide Films and NanostructuresNanoporous metals and alloys

Cellulose Acetate Based Nanocomposites for Biomedical Applications: A Review

Elham N. Bifari、Sher Bahadar Khan、Khalid A. Alamry 等 5 位作者2016-03-16Current Pharmaceutical Design

The development of polymer nanocomposites by incorporating variable nanofillers has attracted attention of scientists, researchers and industrial sectors due to their dramatic improvement in various properties. Cellulose acetate (CA) based nanocomposites have interesting history in the field of medical applications be…

biodegradable polymer synthesis and properties

Synergistic Inhibitory Effect of Peptide–Organic Coassemblies on Amyloid Aggregation

Lin Niu、Lei Liu、Wenhui Xi 等 20 位作者2016-03-16ACS Nano

Inhibition of amyloid aggregation is important for developing potential therapeutic strategies of amyloid-related diseases. Herein, we report that the inhibition effect of a pristine peptide motif (KLVFF) can be significantly improved by introducing a terminal regulatory moiety (terpyridine). The molecular-level obser…

Alzheimer's disease research and treatmentsChemical Synthesis and AnalysisSupramolecular Self-Assembly in Materials

Exciton Brightening in Monolayer Phosphorene via Dimensionality Modification

Renjing Xu、Jiong Yang、Ye Win Myint 等 7 位作者2016-03-16Advanced Materials

Exciton brightening in monolayer phosphorene is achieved via the dimensionality modification of excitons from quasi-1D to 0D. The luminescence quantum yield of 0D-like excitons is >33.6 times larger than that of quasi-1D free excitons. 2D phosphorene with quasi-1D free excitons and 0D-like excitons provides a unique p…

Perovskite Materials and Applications2D Materials and ApplicationsMXene and MAX Phase Materials

Design of Six-Band Terahertz Perfect Absorber Using a Simple U-Shaped Closed-Ring Resonator

Dan Hu、Hongyan Wang、Qiaofen Zhu2016-03-16IEEE photonics journal

We present a simpler and novel design of a six-band terahertz perfect metamaterial absorber (MA) composed of a metal U-shaped closed-ring resonator, a dielectric spacer, and a metal back plate. The numerical simulation results demonstrate that it can perform absorption peaks at six resonant frequencies whose peaks ave…

Antenna Design and AnalysisMetamaterials and Metasurfaces ApplicationsAdvanced Antenna and Metasurface Technologies

P‐Type Transparent Cu‐Alloyed ZnS Deposited at Room Temperature

Rachel Woods-Robinson、Jason K. Cooper、Xiaojie Xu 等 10 位作者2016-03-16Advanced Electronic Materials

All transparent conducting materials (TCMs) of technological practicality are n‐type; the inferior conductivity of p‐type TCMs has limited their adoption. In addition, many relatively high‐performing p‐type TCMs require synthesis temperatures &gt;400 °C. Here, room‐temperature pulsed laser deposition of copper‐alloyed…

ZnO doping and propertiesQuantum Dots Synthesis And PropertiesCopper-based nanomaterials and applications

Effect of Chromium on Corrosion Behavior of P110 Steels in CO2-H2S Environment with High Pressure and High Temperature

Jianbo Sun、Chong Sun、Xueqiang Lin 等 5 位作者2016-03-16Materials

The novel Cr-containing low alloy steels have exhibited good corrosion resistance in CO2 environment, mainly owing to the formation of Cr-enriched corrosion film. In order to evaluate whether it is applicable to the CO2 and H2S coexistence conditions, the corrosion behavior of low-chromium steels in CO2-H2S environmen…

Corrosion Behavior and InhibitionHigh-Temperature Coating BehaviorsHydrogen embrittlement and corrosion behaviors in metals

Heat-transport mechanisms in molecular building blocks of inorganic/organic hybrid superlattices

Ashutosh Giri、Janne‐Petteri Niemelä、Tommi Tynell 等 7 位作者2016-03-16Physical review. B./Physical review. B

Nanomaterial interfaces and concomitant thermal resistances are generally considered as atomic-scale planes that scatter the fundamental energy carriers. Given that the nanoscale structural and chemical properties of solid interfaces can strongly influence this thermal boundary conductance, the ballistic and diffusive…

Advanced Thermoelectric Materials and DevicesThermal properties of materialsThermal Radiation and Cooling Technologies

A Comprehensive Dynamic Model for Magnetostrictive Actuators Considering Different Input Frequencies With Mechanical Loads

Zhi Li、Xiuyu Zhang、Guoying Gu 等 5 位作者2016-03-16IEEE Transactions on Industrial Informatics

Magnetostrictive actuators featuring high energy densities, large strokes, and fast responses are playing an increasingly important role in micro/nano-positioning applications. However, such actuators with different input frequencies and mechanical loads exhibit complex dynamics and hysteretic behaviors, posing a grea…

Electric Motor Design and AnalysisMagnetic Properties and ApplicationsPiezoelectric Actuators and Control

Recent advances in the syntheses of radical-containing macromolecules

Adam J. Wingate、Bryan W. Boudouris2016-03-16Journal of Polymer Science Part A Polymer Chemistry

Tailor-made polymers containing specific chemical functionalities have ushered in a number of emerging fields in polymer science. In most of these next-generation applications the focus of the community has centered upon closed-shell macromolecules. Conversely, macromolecules containing stable radical sites have been…

Organic Electronics and PhotovoltaicsConducting polymers and applicationsCovalent Organic Framework Applications

In situ Transmission Electron Microscopy observation of Ag nanocrystal evolution by surfactant free electron-driven synthesis

E. Longo、Waldir Avansi、Jefferson Bettini 等 5 位作者2016-03-16Scientific Reports

The study of the interaction of electron irradiation with matter and the response of the material to the passage of electrons is a very challenging problem. However, the growth mechanism observed during nanostructural evolution appears to be a broad and promising scientific field in nanotechnology. We report the in si…

Gold and Silver Nanoparticles Synthesis and ApplicationsQuantum Dots Synthesis And PropertiesNanocluster Synthesis and Applications

Discontinuous modulation functions and their application for analysis of modulated structures with the computing system JANA2006

V. Petřı́ček、Václav Eigner、Michal Dušek 等 4 位作者2016-03-16Zeitschrift für Kristallographie - Crystalline Materials

Abstract Discontinuous modulation functions called crenel and saw-tooth have been developed for description and refinement of strongly modulated crystal structures with abrupt changes of modulation parameters. Although used for refinement of many modulated structures and mentioned in books on aperiodic crystals, techn…

Quasicrystal Structures and PropertiesX-ray Diffraction in CrystallographyOptics and Image Analysis

Biodistribution and Pharmacokinetics of Mad2 siRNA-loaded EGFR-Targeted Chitosan Nanoparticles in Cisplatin Sensitive and Resistant Lung Cancer Models

Ana Vanessa Nascimento、Florence Gattacceca、Amit Singh 等 7 位作者2016-03-16Nanomedicine

BACKGROUND: The present study focuses on biodistribution profile and pharmacokinetic parameters of EGFR-targeted chitosan nanoparticles (TG CS nanoparticles) for siRNA/cisplatin combination therapy of lung cancer. MATERIAL & METHODS: Mad2 siRNA was encapsulated in EGFR targeted and nontargeted (NTG) CS nanoparticles b…

Nanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryAndrographolide Research and Applications

Non‐Lithographic Fabrication of All‐2D α‐MoTe2 Dual Gate Transistors

Kyunghee Choi、Young Tack Lee、Jin Sung Kim 等 8 位作者2016-03-16Advanced Functional Materials

As one of the emerging new transition‐metal dichalcogenides materials, molybdenum ditelluride (α‐MoTe 2 ) is attracting much attention due to its optical and electrical properties. This study fabricates all‐2D MoTe 2 ‐based field effect transistors (FETs) on glass, using thin hexagonal boron nitride and thin graphene…

Graphene research and applications2D Materials and ApplicationsMXene and MAX Phase Materials

Tuning the Plasmonic Response up: Hollow Cuboid Metal Nanostructures

Aziz Genç、Javier Patarroyo、Jordi Sancho‐Parramon 等 11 位作者2016-03-16ACS Photonics

High Resolution Image Download MS PowerPoint Slide We report the fine-tuning of the localized surface plasmon resonances (LSPRs) from ultraviolet to near-infrared by nanoengineering the metal nanoparticle morphologies from solid Ag nanocubes to hollow AuAg nanoboxes and AuAg nanoframes. Spatially resolved mapping of p…

Gold and Silver Nanoparticles Synthesis and ApplicationsAdvanced biosensing and bioanalysis techniquesPlasmonic and Surface Plasmon Research

Lipid-Core Nanocapsules Act as a Drug Shuttle Through the Blood Brain Barrier and Reduce Glioblastoma After Intravenous or Oral Administration

Stephen F. Rodrigues、Luana A. Fiel、Ana Lúcia Borges Shimada 等 7 位作者2016-03-16Journal of Biomedical Nanotechnology

Lipid-core nanocapsules (LNC) are formed by an organogel surrounded by poly(epsilon-caprolactone) and stabilized by polysorbate 80. LNCs increase the concentration of drugs in the brain after oral or intravenous administration. We proposed to determine whether the drug is released from the LNC to cross the blood brain…

Nanoparticle-Based Drug DeliveryGlioma Diagnosis and TreatmentDrug Transport and Resistance Mechanisms