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IC‐P‐031: Application of Double Mr Imaging to Detect Amyloid Oligomers in The Brain of APP/PS1 Transgenic Model Mice

Ikuo Tooyama、Daijiro Yanagisawa、Hiroyasu Taguchi 等 8 位作者2016-07-01Alzheimer s & Dementia

We have developed two types of potential imaging agents using F-MRI: F-containing styrylbenzoxazole derivative (Shiga-X22) and curcumin derivative (Shiga-Y5). Shiga-Y5 detects both Aβ oligomers and Aβ aggregates, while Shiga-X22 only detects Aβ aggregates. Thus, the Shiga-Y5 images subtracted by Shiga-X22 may reflect…

Advanced MRI Techniques and ApplicationsLanthanide and Transition Metal ComplexesPrion Diseases and Protein Misfolding

Electrical Characterization of Iodin Post-Doped Amorphous Carbon Thin Films by Natural Precursor

Dayana Kamaruzaman、Muhammad Aliff Rosly、Ishak Annuar 等 5 位作者2016-07-01OpenAlex

Carbon based solar cell has attracted researcher attention as a replacement of silicon for use in solar cell material in the future. The amorphous carbon thin films doped with ptype iodine have been prepared by using a thermal CVD system. In this work, the effect of doping time for the electrical properties of nanostr…

Carbon Nanotubes in CompositesDiamond and Carbon-based Materials ResearchForce Microscopy Techniques and Applications

P1‐076: Development of Bio‐Conjugates for the Treatment of Excitotoxicity During Alzheimer's Disease

Ahlem Zaghmi、Andrea A. Greschner、Marc A. Gauthier 等 4 位作者2016-07-01Alzheimer s & Dementia

Glutamate, as the major excitatory neurotransmitter in the central nervous system is involved in many aspects of normal brain function including learning, memory and behavior (Campos-Peña et al., 2014, Hynd et al., 2004). During Alzheimer’s disease (AD), the high levels of glutamate, induces excitotoxicity and leads t…

3D Printing in Biomedical ResearchSupramolecular Self-Assembly in MaterialsGraphene and Nanomaterials Applications

IC‐P‐184: Comparison of Early Dynamic Amyloid and TAU‐PET Scans to 18F‐FDG‐PET image

Gareth Jones、Victor L. Villemagne、Tia L. Cummins 等 4 位作者2016-07-01Alzheimer s & Dementia

Several studies have shown the utility of the early phase uptake of Ab PET tracers to provide perfusion-like information. The goal of this study was to compare the perfusion-like distribution supplied by early phase of Ab PET tracers C-PiB (PiB) and F-Florbetaben (FBB), as well as the tau tracer F-AV1451 (AV1451), to…

Advanced MRI Techniques and ApplicationsMedical Imaging Techniques and ApplicationsLanthanide and Transition Metal Complexes

Numerical Study of the Features of Ti-Nb Alloy Crystallization during Selective Laser Sintering

А. И. Дмитриев、A. Yu. Nikonov2016-07-01IOP Conference Series Materials Science and Engineering

The demand for implants with individual shape requires the development of new methods and approaches to their production. The obvious advantages of additive technologies and selective laser sintering are the capabilities to form both the external shape of the product and its internal structure. Recently appeared and a…

Bone Tissue Engineering MaterialsAdditive Manufacturing Materials and ProcessesTitanium Alloys Microstructure and Properties

P3‐042: Encapsulation of Amyloid‐Beta Scavenging Compounds into BBB Permeable Nanoparticles

Federica Cioffi、Pia Kröger、Marinke van der Helm 等 8 位作者2016-07-01Alzheimer s & Dementia

Alzheimer’s disease (AD) is a common neurodegenerative disorder characterized by a progressive decline in memory as a result of neuronal cell death. One of the pathological hallmarks of AD includes the accumulation of amyloid-beta (Aβ) toxic oligomers. Many developed small molecule drugs demonstrating neutralizing act…

Nanoparticle-Based Drug DeliveryAlzheimer's disease research and treatmentsAdvanced Drug Delivery Systems

Una teoria di gauge della suscettività magnetica dei cupratiad alta Tc

Dario Spolaor2016-07-01OpenAlex

Nella tesi si discute la suscettivita magnetica nella fase normale dei cuprati superconduttori ad alta Tc, utilizzando un formalismo di gauge basato sulla separazione dei gradi di liberta di carica e spin nelle eccitazioni a bassa energia, confrontando i dati sperimentali con i risultati dei calcoli teorici.

Physics of Superconductivity and MagnetismMagnetic Properties and Applications

P4‐397: RAISING AVAILABLE BRAIN CONCENTRATIONS OF A POTENTIAL ALZHEIMER’S DISEASE DRUG CANDIDATE BY PEPTIDE CYCLIZATION

Anna Elena Schartmann、Sarah Schemmert、Tamar Ziehm 等 8 位作者2016-07-01Alzheimer s & Dementia

Alzheimer’s disease (AD) is a widespread progressive neurodegenerative disease but to date, no curative treatment is established. To target toxic amyloid-beta (Aβ) species and to convert them into non-toxic species, we have developed and designed D-enantiomeric peptides. Here, we investigated if intraperitoneal and in…

Alzheimer's disease research and treatmentsSupramolecular Self-Assembly in MaterialsAmino Acid Enzymes and Metabolism

P1‐262: Comparison of [18F]Flutametamol and [11C]PIB in Normal Young, Normal Elderly, and Alzheimer's Disease Subjects

Val J. Lowe、Matthew L. Senjem、David S. Knopman 等 8 位作者2016-07-01Alzheimer s & Dementia

Multiple F amyloid PET imaging drugs have been approved for clinical use by the FDA. [C]PiB is an amyloid imaging drug used in many research centers. Understanding any variation in uptake patterns between different amyloid drugs is important in cross-amyloid-drug imaging analyses. We performed [F]Flutametamol and [C]P…

Medical Imaging Techniques and ApplicationsLanthanide and Transition Metal Complexes

INCREASE OF THE OPERATIONAL PROPERTIES OF WELD AND PLASMA COATINGS USING NANOPOWDERS

Andrii Chornyi、И. В. Смирнов、Maksym Ziberov 等 5 位作者2016-07-01DOAJ (DOAJ: Directory of Open Access Journals)

In this work, studies concerning determination of the oxide nanoparticles effect on structure and performance of the welds and plasma coatings were conducted. Ways ofintroducing nanodisperse refractory powders to the weld pool and how to cover with thedeactivation of nanoparticles powder were determined. Introducing o…

Material Properties and ApplicationsSurface Treatment and CoatingsAdvancements in Materials Engineering

EC‐01‐02: Structure of Γ‐Secretases and Implications for Drug Development

Xiao‐chen Bai、Eeson Rajendra、Ganghui Yang 等 5 位作者2016-07-01Alzheimer s & Dementia

Human γ-secretase is an intra-membrane protease that cleaves many different substrates. Aberrant cleavage of Notch is implicated in cancer, while abnormalities in cutting amyloid precursor protein lead to Alzheimer's disease. We use cryo-EM structure determination to solve the atomic structure of human γ-secretase, an…

Alzheimer's disease research and treatmentsSupramolecular Self-Assembly in Materials

P2‐211: Subcortical Calcification and Abnormal MRI Signal along the Pyramidal Tracts: A Novel Mutation of CSF1R in Hereditary Leukoencephalopathy with Axonal Spheroids

Jia‐Bao Liu、Liyong Wu、Jieying Li 等 5 位作者2016-07-01Alzheimer s & Dementia

Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is an autosomal dominant hereditary disease, characterized by cerebral white matter degeneration with demyelination and axonal spheroids leading to progressive cognitive and motor dysfunction. HDLS is caused by mutations of the colony-stimulating factor 1 re…

Neuroinflammation and Neurodegeneration MechanismsPolyoxometalates: Synthesis and ApplicationsNeurological Disease Mechanisms and Treatments

Karbon Nano Tüplerin Dispersiyonuna SDS Yüzey Aktif Maddesinin Etkisi

Miraç Alaf、U. Tocoglu、Fuat Kayış 等 4 位作者2016-07-01OpenAlex

Bu çalışmada karbon nano tüplerin (KNT) suda disperse olmasına sodyum dodesil sülfat (SDS) yüzey aktif maddesinin etkisi incelenmiştir. Karbon nano tüpler farklı derişimlerde ki sodyum dodesil sülfat çözeltilerine ultrasonikasyon işlemi ile disperse edilmiş ve bu çözeltilerin zeta potansiyelleri ölçülmüştür.

Gas Sensing Nanomaterials and SensorsElectrospun Nanofibers in Biomedical ApplicationsTribology and Wear Analysis

Corrosion Control of Central Vehicle Wash Facility Pump Components Using Alternative Alloy Coatings

Michael McInerney、Robert Jr B. Mason2016-07-01OpenAlex

Central Vehicle Wash Facilities CVWFs at military installations are essential for supporting the readiness of tactical vehicles. Steel wash-rack pumps are vulnerable to accelerated degradation where supply water is corrosive and infused with fines. Pump failure can occur with little warning, taking the CVWF out of ser…

Engineering and Material Science ResearchLife Cycle Costing Analysis

CM1106 STEMCHEM : chemical approaches to targeting drug resistance cancer stem cells

Pierre Schembri-Wismayer、Analisse Cassar、Krystle Blaire Theuma 等 7 位作者2016-07-01OAR@UM (University of Malta)

STEMCHEM is a COST action aiming to target causes of drug resistance in cancer stem cells. Cancer stem cells are cells which are believed to be responsible for the larger part of the regenerative capacity of cancers. They are also thought to be similar to adult stem cells in that they do not proliferate most of the ti…

Nanoparticle-Based Drug DeliveryGraphene and Nanomaterials Applications

High performance transmission lines using the Spoof Surface Plasmon Polaritons

Jun Feng Liu、Hao Chi Zhang、Wenxuan Tang 等 4 位作者2016-07-01OpenAlex

Low-loss and high interference-suppression transmission lines (TLs) are presented in this paper by introducing field confinement in the Spoof Surface Plasmon Polartions (SPPs). By changing the dispersion behavior of SPP mode, the field confinement can be controlled. And the loose confinement of field leads to a lower-…

Metamaterials and Metasurfaces ApplicationsPlasmonic and Surface Plasmon ResearchPhotonic Crystals and Applications

Research of a circulator based on spoof surface plasmon polaritons

Tianshuo Qiu、Jiafu Wang、Yongfeng Li 等 4 位作者2016-07-01OpenAlex

This paper shows a study of a new kind of circulator with spoof surface plasmon polaritons (SSPPs). In this letter, the combination of SSPPs and Y-junction in inner conductor is in consideration. SSPPs transmission mode and TEM mode is dominant in different band. That makes the broadband characteristic of the circulat…

Metamaterials and Metasurfaces ApplicationsPlasmonic and Surface Plasmon ResearchFull-Duplex Wireless Communications

Compact planar diplexer using OSL-CRLH resonators

Mengze Li、Kai‐Da Xu2016-07-01OpenAlex

A new compact planar diplexer at 2.75 and 3.45 GHz consisting of two connected bandpass filters using open-stub loaded composite right/left-handed (OSL-CRLH) resonators has been presented. For this miniaturized diplexer, the center frequencies and bandwidths of two passbands can be determined by the sizes of their CRL…

Metamaterials and Metasurfaces ApplicationsMicrowave Engineering and WaveguidesAdvanced Antenna and Metasurface Technologies

Dual-band asymmetric transmission and cross-polarization conversion of linearly polarized wave using multi-layered metamaterial

Yajun Liu、Song Xia、Hongyu Shi 等 5 位作者2016-07-01OpenAlex

In this paper, we propose a multi-layered metamaterial that consists of three metallic layers and two dielectric spacer layers to realize efficient dual-band asymmetric transmission for linearly polarized wave. The simulated results show that the metamaterial can achieve broadband and high efficiency cross-polarizatio…

Antenna Design and AnalysisMetamaterials and Metasurfaces ApplicationsAdvanced Antenna and Metasurface Technologies