Materials Literature
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OBJECTIVE: To present the CSF1R screening in 218 PPMS patients and to report the clinical features of a case of Hereditary Diffuse Leukoencephalopathy with Spheroids (HDLS) with a novel CSF1R mutation, who was initially diagnosed as PPMS. BACKGROUND: HDLS is a devastating hereditary, white matter (WM) disorder with he…
OBJECTIVE: A unique case report on extrapontine myelinolysis (EPM) presenting as parkinsonism. BACKGROUND: EPM is a rare complication (10% of osmotic demyelination cases) of rapid correction of hyponatremia associated with diverse presentations and outcomes. This is a unique case of EPM due to severe parkinsonism, unr…
Si riporta la misura della percentuale di carbonio moderno di n. 7 campioni di polimeri organici fornite dalla ditta Granarolo spa, per la determinazione del contenuto bio delle plastiche utilizzate nel confezionamento dei prodotti alimentari.
La mise en forme de matériaux fonctionnels et leur texturation contrôlée à toutes les échelles sont des conditions sine qua non pour l’amélioration des systèmes existants. Ce projet de thèse consiste en la création de structures solides complexes en utilisant des méthodes interdisciplinaires telles que la chimie sol-g…
Molybdenum cofactor (Moco) biosynthesis is an ancient, ubiquitous, and highly conserved pathway leading to the biochemical activation of molybdenum. ModE enhances the transcription of molybdenum-dependent enzymes like DMSO reductase or nitrate reductase A and also of the molybdenum cofactor biosynthesis operon moaABCD…
BACKGROUND PML is a rare complication of natalizumab therapy. The diagnosis relies mainly on the detection of the JCV in CSF and on MRI. Large T2 hyperintense and T1 hypointense lesions are typically observed. Punctuate gadolinium-enhancement in vicinity of the T2 hyperintense lesions, is observed in 40% of cases, in…
OBJECTIVE: 1) to measure intracellular and extracellular sodium concentration (ISC and ESC) in MS patients using sodium MRI at 7T; 2) to investigate the associations between total sodium concentration (TSC), ISC and ESC and measures of lesion and brain volume; 3) to assess the clinical significance of ISC and ESC. BAC…
OBJECTIVE:To evaluate the prognostic role of CSF Neurofilament Light Chain (NFL) levels in predicting the conversion to definite MS in patients at first clinical episode suggestive of MS BACKGROUND:Increased concentrations of CSF NFL levels have been reported in patients with MS since the earliest stage of the disease…
Climate change is one of the biggest challenges facing the world. The largest contributor to climate change is the greenhouse gas CO2, which is released through anthropogenic activities such as burning of fossil fuel and agricultural waste. To find solutions to mitigate climate change, research has been proposed to re…
OBJECTIVE: To compare PIB retention in early- and late-onset temporal-variant frontotemporal dementia (tvFTD), Alzheimer's disease (AD), and controls. BACKGROUND: The amyloid tracer, Pittsburgh compound B (PIB), identifies amyloid-β (Aβ) deposition in patients with AD. Frontotemporal dementia (FTD) patients typically…
Objective To determine how alpha-synuclein oligomers induce neurotoxicity Background Neurodegenerative diseases share a common process of misfolding of a native monomeric protein into an intermediate oligomeric structure, and ultimately depositing as insoluble fibrils in the brain. In sporadic Parkinson’s disease (PD)…
OBJECTIVE: To assess the feasibility of noninvasive sensory and motor peroneal nerve conduction studies from the rabbit distal hindlimb and measure their response to the neurotoxin, vincristine. BACKGROUND: The peroneal nerve anatomy of the rabbit distal hindlimb is similar to humans, but reports of noninvasive nerve…
OBJECTIVE To explore the structural-metabolic networks in Alzhemier disease towards finding of early marker of disease. BACKGROUND Multiple MRI biomarkers of Alzheimer’s disease have been reported in the past few years, however, no single modality has reached sufficient level of accuracy in diagnosis of early disease.…
In this paper, we consider the behavior of the inhomogeneous single-layer beam under alternating load (pressure), distributed uniformly over its entire surface. The research is conducted from the perspective of the qualitative theory of differential equations and nonlinear dynamics. Construct a theory of nonlinear dyn…
The most universally known and the most often misquoted is “Whatever is true for E. coli is true for an elephant.” Jacques Monod's faith in the universality of the laws and mechanisms of biology contrasting with his provocative attitude of apparent cynicism in front of the great problems of “the secrets of life” was f…
Le transformateur est aujourd’hui l’un des convertisseurs statiques les plus utilise notamment dans la distribution electrique. Les toles magnetiques servant a la construction de leurs circuits magnetiques sont devenues de plus en plus performantes permettant une reduction des pertes produites. Neanmoins, les tests no…
Nothing could be more central to US. and world security than ensuring that nuclear warheads and their essential ingredients-plutonium and highly enriched uranium (HEU)-do not fall into the hands of terrorists or proliferating states. If plutonium and HEU find their way onto a nuclear black market, nothing else we do t…
Enzymes involved in the degradation of substrates similar in structure seemed likely to derive from the same precursor. For this reason Monod decided to study the enzymes involved in the degradation of two similar disaccharides: lactose and maltose. As a result, two communications were presented on July 12, 1948, at t…
OBJECTIVE: Evaluate ONO-4641 (ceralifimod) therapeutic effect using longitudinal magnetic resonance imaging (MRI) in an animal model of multiple sclerosis (MS). BACKGROUND: MRI is a well-established tool for diagnosing, monitoring disease progression, and evaluating therapeutic efficacy in MS. In MS animal models, MRI…
Pristine and organoclay modified polycarbonate/polystyrene (PC/PS) blends are prepared using melt-mixing technique. These blends are characterized for their morphology, structural, thermal and mechanical properties. Though our FTIR and XRD results show weak interactions between PC and PS phases, however, DSC and morph…