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Conformational instability of human prion protein upon residue modification: a molecular dynamics simulation study

Kourosh Bamdad、Hossein Naderi‐Manesh、A. Baumgærtner2014-03-03PubMed

Technical strategies like amino acid substitution and residue modification have been widely used to characterize the importance of key amino acids and the role that each residue plays in the structural and functional properties of protein molecules. However, there is no systematic approach to assess the impact of the…

Protein Structure and DynamicsEnzyme Structure and FunctionPrion Diseases and Protein Misfolding

Assessment of the Cast Stone Low-Temperature Waste Form Technology Coupled with Technetium Removal - 14379

Christopher F. Brown、Brian M. Rapko、R. Jeffrey Serne 等 9 位作者2014-03-03OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)

The U.S. Department of Energy Office of Environmental Management (EM) is engaging the national laboratories to provide the scientific and technological rigor to support EM program and project planning, technology development and deployment, project execution, and assessment of program outcomes. As an early demonstrati…

Radioactive element chemistry and processingGraphite, nuclear technology, radiation studiesNuclear and radioactivity studies

RECENT PROGRESS IN THE DEVELOPMENT OF DUCTILE-PHASE TOUGHENED TUNGSTEN FOR PLASMA-FACING MATERIALS

Charles H. Henager、Richard J. Kurtz、Timothy Roosendaal 等 9 位作者2014-03-03OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)

The objective of this study is to develop the materials science of fiber-reinforced tungsten composites as candidates for plasma-facing components in future fusion reactors.

Metal and Thin Film MechanicsFusion materials and technologiesAdvanced materials and composites

Observation of possible topological in-gap surface states in the Kondo insulator SmB$_{6}$ by photoemission

Juan Jiang、Sheng Li、Tong Zhang 等 16 位作者2014-03-03RePEc: Research Papers in Economics

Abstract SmB6, a well-known Kondo insulator, exhibits a transport anomaly at low temperature. This anomaly is usually attributed to states within the hybridization gap. Recent theoretical work and transport measurements suggest that these in-gap states could be ascribed to topological surface states, which would make…

Rare-earth and actinide compoundsMagnetic Properties of AlloysSuperconducting Materials and Applications

An Insight into Grain Refinement Mechanism of Ultrananocrystalline Diamond Films Obtained by Direct Current Plasma-Assisted Chemical Vapor Deposition

Hak‐Joo Lee、Jung‐Min Cho、Inho Kim 等 7 位作者2014-03-03Plasma Processes and Polymers

The grain-refinement mechanisms involved during the deposition of diamond films by direct-current plasma assisted chemical vapor deposition (DC-PACVD) were investigated as a function of the inter-electrode electric field (IEEF). As IEEF was increased from 260 to 940 V cm−1, the local electron temperatures near the gro…

Metal and Thin Film MechanicsHigh-pressure geophysics and materialsDiamond and Carbon-based Materials Research

Graphene modelocked VECSELs

C. A. Zaugg、Valentin J. Wittwer、Z. Sun 等 13 位作者2014-03-03Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

In the past decade, passively modelocked optically pumped vertical external cavity surface emitting lasers (OPVECSELs), sometimes referred to as semiconductor disk lasers (OP-SDLs), impressively demonstrated the potential for generating femtosecond pulses at multi-Watt average output powers with gigahertz repetition r…

Diamond and Carbon-based Materials ResearchAdvanced Fiber Laser TechnologiesSemiconductor Lasers and Optical Devices

Biomolecular sensing for cancer diagnostics using highly reproducible SERS substrates

Anna Chiara De Luca、Peter Reader-Harris、Michaël Mazilu 等 7 位作者2014-03-03Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

We developed a SERS biosensor based on gold fishnets fabricated by using e-beam lithography. This device is used for glycerophosphoinositol (GroPIns) molecule sensing. GroPIns is an abundant component of cell cytosol and high GroPIns levels have been reported in several tumour cells. We demonstrate that our SERS senso…

Gold and Silver Nanoparticles Synthesis and ApplicationsAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical Detection

Plasmonic spectra of individual subwavelength particles under the infrared microscope: cells and airborne dust

James V. Coe、David B. Lioi、Lindsey Shaffer 等 6 位作者2014-03-03Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

A plasmonic metal film with a subwavelength hole array (a mesh) is used to capture an individual subwavelength particle, like a single yeast cell or airborne dust particle, and an imaging infrared (IR) microscope, records a scatterfree, IR absorption spectrum of the particle. Individual spectra of wavelength scale par…

Gold and Silver Nanoparticles Synthesis and ApplicationsPlasmonic and Surface Plasmon ResearchThermal Radiation and Cooling Technologies

Metal-enhanced fluorescence of chlorophylls in light-harvesting complexes coupled to silver nanowires

Magdalena Twardowska、Dorota Kowalska、Maria Olejnik 等 4 位作者2014-03-03Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

We present passive mode locking of a vertical external-cavity surface-emitting laser (VECSEL) in the red spectral range. The gain structure includes 20 compressively strained GaInP quantum wells (QWs), which are arranged in a resonant periodic gain design containing five packages of four quantum wells each. We use ten…

Gold and Silver Nanoparticles Synthesis and ApplicationsAdvanced biosensing and bioanalysis techniquesQuantum Dots Synthesis And Properties

Enhanced sulphidation/oxidation resistance of Ti–45Al–8Nb alloy by multilayered coatings at 850°C for up to 675 h

T. Dudziak、Hailiang Du、P.K. Datta 等 6 位作者2014-03-03Corrosion Engineering Science and Technology The International Journal of Corrosion Processes and Corrosion Control

The high temperature sulphidation/oxidation behaviour of three multilayered coatings CrAlYN/CrN etched by Y+, CrAlYN/CrN etched by Cr+ and CrAlYN/CrN etched CrAl+ and the uncoated γ-TiAl (Ti–45Al–8Nb (at-%) used as reference sample was studied at 850°C for 675 h. Sulphidation/oxidation test was performed in the enviro…

High-Temperature Coating BehaviorsIntermetallics and Advanced Alloy PropertiesMXene and MAX Phase Materials

Graphene saturable absorbers for VECSELs

Valentin J. Wittwer、C. A. Zaugg、Z. Sun 等 13 位作者2014-03-03Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

We report mode-locking of an optically pumped VECSEL using a graphene-based saturable absorber mirror (GSAM). Self-starting and stable modelocked operation is demonstrated with 473 fs pulses at 1.5 GHz repetition rate and 949 nm center wavelength. Wavelength tuning is achieved over a 46 nm bandwidth. We discuss the mi…

Photonic and Optical DevicesDiamond and Carbon-based Materials ResearchAdvanced Fiber Laser Technologies

Titelbild: Monitoring Conformational Changes in the NDM‐1 Metallo‐β‐lactamase by 19F NMR Spectroscopy (Angew. Chem. 12/2014)

Anna M. Rydzik、Jürgen Brem、Sander S. van Berkel 等 7 位作者2014-03-03Angewandte Chemie

Antibiotikaresistenz ist ein weltweites Gesundheitsproblem. Metallo-β-lactamasen katalysieren die Hydrolyse von nahezu allen β-Lactam-Antibiotika. T. D. W. Claridge, C. J. Schofield et al. zeigen in ihrer Zuschrift auf S. 3193 ff., wie 19F-NMR-Spektroskopie genutzt werden kann, um die Bindungsweise von Inhibitoren der…

Metabolomics and Mass Spectrometry StudiesEnzyme Structure and FunctionChemical Reactions and Isotopes

X-ray crystal structures of Al-doped (Y,Ca)Ba2Cu3O7−ywhiskers

Federica Bertolotti、Leandro Calore、Giuliana Gervasio 等 6 位作者2014-03-03Acta Crystallographica Section B Structural Science Crystal Engineering and Materials

Al(+3)-doped (Y,Ca)Ba2Cu3O(7-y) (YBCO) whiskers have been synthesized using a solid-state reaction technique. These materials are promising candidates for solid-state THz applications based on sequences of Josephson Junctions (IJJs). Alumina addition was systematically varied and the effect of aluminium incorporation…

Physics of Superconductivity and MagnetismAdvanced Condensed Matter PhysicsIron-based superconductors research

Crystal structure of oxonium o-toluidinium sulfate at 100K, (C7H10N)(H3O)SO4

C. Ben Hassen、Mohamed Boujelbene、Mohamed Khitouni 等 5 位作者2014-03-03Mediterranean Journal of Chemistry

A simple oxonium o-toluidinium sulfate, (C7H10N)(H3O)SO4 , crystallized from water at ambient temperature was found to be monoclinic (space group P21/c) at 100K. In the crystal, the H3O+ ions and the SO42- anions are linked by O-H…O hydrogen bonds, generating infinite layers lying parallel to the bc plane at x = 1/2.…

Crystal structures of chemical compoundsCrystallography and molecular interactionsSolid-state spectroscopy and crystallography

Understanding the nanophotonic light-trapping structure of diatom frustule for enhanced solar energy conversion: a theoretical and experimental study

Xiangfan Chen、Chen Wang、Evan Baker 等 5 位作者2014-03-03Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

Recent designs in nanophotonic light-trapping technologies offer promising potential to develop high-efficiency thin-film solar cell at dramatically reduced cost. However, the lack of a cost effective scalable nanomanufacturing technique remains the main road-block. In nature, diatoms exhibit high solar energy harvest…

Microbial Fuel Cells and BioremediationAnalytical Chemistry and SensorsDiatoms and Algae Research

Low-cost, high-sensitivity SERS nano-bio-chip for kinase profiling, drug monitoring and environmental detection: a translational platform technology

Yi Chen、Logan Liu2014-03-03Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

The interaction of biomolecules and solid-state nanomaterials at the nano-bio interfaces is a long-lasting research topic in nanotechnology. Historically, fundamental problems, such as the electron transfer, energy transfer, and plasmonic interaction at the bio-nano interfaces, have been intensively studied, and revol…

Gold and Silver Nanoparticles Synthesis and ApplicationsAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical Detection

Quantifying local density of optical states of nanorods by fluorescence lifetime imaging

Jing Liu、Xunpeng Jiang、Satoshi Ishii 等 5 位作者2014-03-03Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

Engineering of quantum emissions is regarded as the heart of nano-optics and photonics; local density of optical states (LDOS) around the quantum emitters are critical to engineer quantum emissions, thus detection of the LDOS will impact areas related to illumination, communication, energy, and even quantum-informatic…

Gold and Silver Nanoparticles Synthesis and ApplicationsQuantum Dots Synthesis And PropertiesNear-Field Optical Microscopy

The effect of surface charge of plasmonic gold nanoparticles on photoacoustic signal

Miya Ishihara、Takeshi Hirasawa、Shinpei Okawa 等 6 位作者2014-03-03Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

We investigated the effects of surface charge of gold nanoparticles (Au NPs) on photoacoustic (PA) signal from cultured cancer cell. We used citrated-coated Au NPs and poly-L-lysine-coated Au NPs as the model of negatively and positively charged Au NPs, respectively. Transmission electron microscopy (TEM) were perform…

Gold and Silver Nanoparticles Synthesis and ApplicationsNanoplatforms for cancer theranosticsPhotoacoustic and Ultrasonic Imaging

Amiotrofična lateralna skleroza

Mira Bučuk、Kristina Dijan、Zoran Tomić 等 4 位作者2014-03-03Hrčak Portal of scientific journals of Croatia (University Computing Centre)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive muscular weakness. It affects both upper and lower motor neurons. Affected individuals typically present with either asymmetric weakness of the extremities or with bulbar symptoms (dysarthria, dysphagia). Weakness is alway…

Parkinson's Disease Mechanisms and Treatmentsbiodegradable polymer synthesis and propertiesAmyotrophic Lateral Sclerosis Research

Fractional complexation in a miscible polymer blend. Calorimetry and size exclusion chromatography

Jaroslav Kratochvíl、Adriana Šturcová、Antonín Sikora 等 4 位作者2014-03-03Polymer International

Poly(N‐methyldodecano‐12‐lactam) (PMDL) is miscible with poly(4‐vinylphenol) (PVPh). In the system PMDL + PVPh + tetrahydrofuran containing low‐molar‐mass polymer pair, this miscible blend is soluble in the solvent. In this work, it has been found that the system containing high‐molar‐mass polymer pair undergoes assoc…

Polymer crystallization and propertiesMaterial Dynamics and PropertiesPolymer Nanocomposites and Properties