Materials Literature
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Abstract : This report describes the design, operation, and performance assessment of an apparatus, whereby a planar equi-biaxial strain may be applied to a circular membrane in a precisely controlled and repeatable manner. The strained state may be held indefinitely to enable the study of mechanical creep and other p…
Lung cancer, the leading cause of cancer mortality, annually kills 1.4M people. Despite advances in surgery, drug discovery and therapy, lung cancer remains a difficult disease to treat. We propose that targeted inhaled drug delivery to the respiratory tract will facilitate treatment with lower systemic exposure and c…
Hydrogels are crosslinked polymer networks that store large amounts of water. Their biophysical similarity to soft biological tissues makes them of great use to the biomaterials research community. In general, the crosslinked structure of hydrogels is characterized by junctions or tie points. Berberine was used as a m…
Since the first genomes were sequenced, there has been an exponential increase of protein sequences deposited into databases worldwide. This increase in sequence data has allowed for dramatic improvements in our understanding of the metabolism of organisms. Unfortunately, as the number of protein sequences grows, the…
University of Minnesota Ph.D. dissertation. April 2013. Major: Material Science and Engineering. Advisor: C. Daniel Frisbie. 1 computer file (PDF); x, 173 pages.
Abstract : JBA proposes a program of targeted construction and demolition activities intended to improve its operational efficiency and ensure that the installation can sustain its current and future national security operations and mission-readiness status. The proposed activities are: * Construct a Helicopter Operat…
Purpose Tendon force transmission depends on the length and mechanical behavior of collagen fibrils, two poorly understood parameters. Methods Collagen fibrils from rat‐tail tendons (RTT) and human patellar tendons (HPT) were mechanically tested to failure using atomic force microcopy (AFM). The effect of cross‐link s…
Background The phenothiazine dye methylene blue (MB) has antioxidant properties and augments ATP production, and is selectively internalized by neurons after systemic injection into rats. Hypothesis MB protects neurons against hypoxia‐reoxygenation (H/R) injury by enhancing ATP production and activating the Akt/mTOR s…
The authors have demonstrated that coefficients of deformation and strength of metals can be applied to identify interrelationship between their shear stress and fatigue strength values.δThe authors have found that coefficient of proportionality ƒconnecting tensileвstrength σand hardness HB of magnesium alloys varies…
Negative investor sentiment towards the uranium sector is doing nothing to deter Cauldron Energy Ltd from fulfilling its own yellowcake ambitions with the company launching an off-market all-scrip offer for fellow junior Energia Minerals Ltd.
This study examines the wearing comfort of elderly women through a physiological analysis based on rectal temperature and biochemical analysis with salivary melatonin and cortisol. This study was conducted on 7 elderly women aged 65 or over. Two kinds of clothing ensemble (control and prototype) were used as experimen…
Initiated and oxidative chemical vapor deposition (iCVD/oCVD) are novel surface polymerization techniques for the formation of polymer thin films. Taking advantage of a vacuum environment, polymer CVD enables the synthesis of stoichiometric polymers that can be applied on different surface geometries down to nanometer…
People with diabetes suffer from accelerated atherosclerosis, which is linked to endothelial cell dysfunction in high glucose. Glucose affects endothelial cells directly and glycates basement membrane collagen. Endothelial cells are exposed to cyclic stretch in vivo and align their actin cytoskeleton and remodel the b…
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International audience
This study tested the hypotheses that hyperthermia impairs the capacity to increase cerebral perfusion to a cognitive task (i.e., activation‐flow coupling) and that changes in activation‐flow coupling are related to decrements in cognitive performance during hyperthermia. Changes in mean middle cerebral artery blood v…
The first step in purine biosynthesis converts PP 1 ‐ribose‐P (PPRP) and glutamine into β‐P‐ribosylamine (PRA) and glutamate. The enzyme that catalyzes this reaction is called phosphoribosylpyrophosphate amidotransferase (GPATase or PurF). This enzyme has been extensively characterized in both prokaryotes ( Bacillus s…
Nanotechnology has often been applied in the drug delivery systems for the treatment of cancer. An ideal nanoscale system for drug delivery should be able to selectively deliver and rapidly release the carried therapeutic drug(s) in cancer cells and, more importantly, not react to off‐target cells. To reach this goal,…
The axolotl Ambystoma mexicanum is one of the most used model organisms in evolutionary, developmental and regenerative studies, particularly because it is commonly said that it can reconstitute a completely normal and functional fore/hindlimb after amputation. Surprisingly, there is not a publication that tested the…
The major objective of this study was to investigate the effectivenees of Tricalcium phosphate drug delivery system (TCP) to release steroid and protein hormones at sustained levels for long duration. A total of 70 TCP capsules were fabricated following standard lab protocols. The capsules were randomely divided into…