Materials Literature
按标题、摘要、年份、主题和来源检索公开元数据。结果保留作者、摘要、分类与原始来源链接。
The aim of this work was to develop paclitaxel-liposome loaded microbubbles (PTX-loaded MBs) and to investigate the efficacy of chemotherapy through ultrasound-triggered drug delivery in vitro and in vivo. PTX-loaded liposomes were prepared by a minor modification of thin film hydration method and further conjugated t…
Abstract Objective: Preclinical studies have demonstrated that CFAK-C4 has anti-tumor efficacy in a variety of malignancies. To maximize its efficacy, it is necessary to understand the pharmacokinetic (PK) properties of CFAK-C4 in the body. A PK study was conducted to characterize CFAK-C4 disposition in plasma and var…
This document discusses open literature reports which investigate the damage effects of neutron and gamma irradiation on polymers and/or epoxies - damage refers to reduced physical chemical, and electrical properties. Based on the literature, correlations are made for an SNL developed epoxy (Epon 828-1031/DDS) with an…
First, the historical fact of the discovery of carbon nanotubes is reviewed. Then, production of high crystallinity multi-walled carbon nanotubes by DC arc discharge evaporation of pure graphite rod in pure hydrogen gas is discussed. The smallest carbon nanotubes included in the core of the multi-walled carbon nanotub…
Compared to the conventional bubble type used for PEMFC (proton exchange membrane fuel cell) humidification, ultrasonic atomization has the advantages of smaller size, it is easy to refill and change temperature, and, more importantly, humidity controllability. To improve the performance of the FC, this study develope…
This manual documents the Lawrence Livermore National Laboratory (LLNL) Fire Protection Program. Department of Energy (DOE) Orders 420.1B, Facility Safety, requires LLNL to have a comprehensive and effective fire protection program that protects LLNL personnel and property, the public and the environment. The manual p…
Although the general principles of biomass gasification are broadly understood, at a larger scale of operation (e.g. > 200 kg/h) there is a lack of confidence in the translation of the basic scientific concepts into a financially viable operation that satisfies regulatory requirements. Looking in particular at the ope…
INL recently participated in FUMEX-III, an International Atomic Energy Agency sponsored fuel modeling Coordinated Research Project. A main purpose of FUMEX-III is to compare code predictions to reliable experimental data. During the same time period, the INL initiated development of a new multidimensional (2D and 3D)…
Abstract In the continuing search for effective treatments for cancer, here we report the rational engineering of a novel multifunctional nanoparticle that combines traditional chemotherapy with cell targeting and anti-cellular-adhesion functionalities to selectively target multiple myeloma (MM) cells and overcome cel…
Comprehensive sensitivity and uncertainty analysis has been performed for light-water reactor and heavy-water reactor lattices using three techniques; adjoint-based sensitivity analysis, Monte Carlo sampling, and direct numerical perturbation. The adjoint analysis was performed using a widely accepted, commercially av…
The power ultrasound effects, the sonocrystallization kinetics and mechanism are investigated for cooling crystallization of l-glutamic acid (LGA) from aqueous solution. Sonocrystallization experiments involving slow and crash cooling have been undertaken for the metastable zone width and induction time measurement. L…
Space charge has been recognized as an important factor contributing to the electrical failure of the cable insulation. Extensive efforts have been made to investigate space charge dynamics within polymeric insulations under electric stresses. Basic information about space charge has been recognized resorting to moder…
This project is a fundamental study to measure thermal properties (liquidus, solidus, phase transformation, and enthalpy) of molten salt systems of interest to electrorefining operations, which are used in both the fuel cycle research & development mission and the spent fuel treatment mission of the Department of Ener…
Abstract Not Provided
Electrochemical supercapacitors (ES) have become an attractive research interest in advanced power systems and found many applications as an energy storage device in number of areas. The fabrication of advanced electrodes with novel materials and new techniques plays a key part in determining the properties of ES. Con…
Core bypass flow has been one of key issues in the very high temperature reactor (VHTR) design for securing core thermal margins and achieving target temperatures at the core exit. The bypass flow in a prismatic VHTR core occurs through the control element holes and the radial and axial gaps between the graphite block…
Abstract A major challenge in personalized healthcare is predicting how effective a drug treatment is. This is particularly the case in oncology, where there is a call for better therapy monitoring to maximize drug treatment effectiveness leading to improved patient survival and help reduce healthcare costs. GE152, a…
The U.S. Department of Energy (DOE) Hanford Site contains more than 53 million gallons of legacy waste generated as a byproduct of plutonium production and reprocessing operations. The wastes are a complex mixture composed mostly of NaNO3, NaNO2, NaOH, NaAlO2, Na3PO4, and Na2SO4, with a number of minor and trace metal…
The thermochemical copper-chlorine (Cu-Cl) cycle for hydrogen production includes three chemical reactions of hydrolysis, decomposition and electrolysis. The decomposition of copper oxychloride establishes the high-temperature limit of the cycle. Between 430 and 530 oC, copper oxychloride (Cu2OCl2) decomposes to produ…
Abstract Docetaxel is one of the most commonly prescribed anticancer agents. While efficacious, the therapeutic benefits of docetaxel are often compromised by immunosuppression and neurotoxicity, incurring a discontinuation rate of over 25%. Cerulean has developed a novel class of tumor-targeted nanopharmaceuticals de…