Materials Literature
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シスプラチンは肺がん, 胃がん, 膀胱がんの標準治療薬である。しかしながら, 腎毒性や神経毒性のような副作用のため治療を中断することがある。ドラッグデリバリーシステムにより副作用を抑制し, 腫瘍内のシスプラチン量を増加させることは価値あるアプローチといえる。NC-6004は片岡らにより新規なシスプラチンのデリバリーシステムとして考案された。活性を保持したままシスプラチンでみられる腎毒性と神経毒性を抑制したものである。NC-6004の臨床第1相試験は進行癌患者を対象に英国で実施された。片岡らが発明したドキソルビシン結合体と同様にエピルビシンをpH応答性ミセルとした。動物モデルにおいてpH応答性エピルビシンミセルの抗腫瘍活性はエピルビ…
High-power pulsed spallation neutron sources are being developed in the world. A mercury target is installed at MLF ( Materials and Life science experimental Facility ) in J-PARC (Japan Proton Accelerator Research Complex), which will promote innovative science. At the moment the proton beams bombard the mercury targe…
The aim of this study is to clarify formability by conical cup test at room temperature of AZ31 magnesium alloy strip produced by the melt drag process. The strip produced by melt drag process was solution heat treated at 400°C, then was rolled with 5% reduction. We investigated the microstructure, crystal orientation…
Diamond synthesis on fine metal wire was performed effectively using hot filament chemical vapor deposition (CVD). Diamond deposition is difficult when using wire as a substrate because the substrate overheats easily. Touching the substrate directly with a cooling board is effective in such cases, but that technique i…
The focus of this investigation was to develop a simple, high-yield synthetic approach to heterometallic diketonates using the same construction principles as for their polynuclear homometallic analogs. Several low-temperature solid-state synthetic routes were suggested that appear to be general for the preparation of…
In order to evaluate the cracking strength of a gas nitrided layer on a tool steel substrate, four-point bending tests were performed on two specimens nitrided by different companies. The results showed that cracks were introduced in a direction perpendicular to the loading direction after the beginning of plastic def…
FlandersBio and Centexbel join forces to organize a Biomedical Textile seminar focusing on 'Life Sciences & Textile Technology' collaborations.The main goal is to initiate cross-cluster interactions and to develop interdisciplinary research ideas leading to innovations and valorisation opportunities.
A mathematical model has been developed describing the pharmacokinetics of Hoechst 33342 following administration into a culture medium containing a population of transfected cells (HEK293 hBCRP) with a potent inhibitor of the BCRP, Fumitremorgin C (FTC), present. [...]
Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, m…
Metallic pipe is produced to meet API, ISO or other industry specifications. When the manufacturing process involves welding of a longitudinal or spiral seam, the welding is typically done to the standards of ASME Section IX. Girth welding of pipe is often performed using ASME Section IX standards and pulsing waveform…
The current work aims to point out the influence of sour brine environment on the fatigue resistance of welded SMLS (seamless) steel pipe used for design and fabrication of risers for oil and gas development. A C-Mn steel X65 pipe 10.75″ (273.1 mm) outside diameter (OD) and 25.4 mm wall thickness (WT) was chosen for t…
Objectives: A realistic way for obtaining local tissue regeneration is by local application of cells, known as cell therapy. Embryonic stem cells (ES) are often considered for this. As a basic step towards cell therapy, we evaluated the infiltrative behavior of murine and human embryonic stem cells in two known in vit…
This paper describes an overview of the nuclear regulatory framework of Korea such as licensing process and preoperational inspection program for the new reactor, etc. In addition, this paper has been prepared to share the information on the regulatory issues in new reactors that have been granted construction permit…
Novel polyolefin elastomers, HMS POE and OBC were introduced. HMS POE is a high melt strength ethylene-α-olefin random copolymer with certain level of long chain branches and high molecular weight which have provided unique rheological properties such as higher melt strength, higher melt elasticity, shear shining prop…
We have investigated crystallization behavior of cordierite-based oxynitride glass made by melting procedure of the powder mixture of cordierite and silicon nitride. The results clearly indicated that two polymorphs exist, a stable α form that has significant low coefficient of thermal expansion and a metastable μ for…
Plunging jets play an important role in nuclear reactor safety research. In the present paper the case of the strainer clogging issue is considered. Entrained air caused by a plunging jet has an influence of the liquid flow field and on the fibre transport in the sump. In the paper the amount of entrained air is given…
The purpose of this work is two fold: it describes the proof of concept of the newly introduced bulk video imaging (BVI) method and it presents the nucleation detection in comparison with existing process analytical technologies (PAT) such as focused beam reflectance measurement (FBRM) and ultra violet/visible (UV/Vis…
This paper provides a status report on the ASME Section III Subgroup on Design Environmental Fatigue Action Plan. The plan will direct development of ASME Section III Code [1] changes to provide guidance on acceptable methods for evaluating reactor water environment effects on reactor coolant pressure boundary compone…
For further understanding of the interactions between different materials in the electromagnetic metamaterials, the change characteristics of the effective permittivity of wire array embedded in a single negative permeability medium were analyzed theoretically. The interactions between the single negative permittivity…
Fullerenes, first reported by Kroto, are the carbon materials which only carbons connect 60 or more. Since such greatly unique materials were discovered, researches of fullerenes have been addressed a lot. In this report, we had prepared the composites which added the fullerenes to thermoplastic polyurethanes and styr…